Issues

• Default tolerance of 5 mDa is narrower than the MS2 peak width for small ions; 8 mDa removes a series of real ions at no cost to noise detection

  enhancement
  metabolomics-us/impossible-mass-denoise#35 · Filter by author berlinguyinca opened on Oct 23, 2026
  1

• Labelled standards still lost on TTOF and QTOF: mass accuracy, not deuterium; recommend no denoising there

  metabolomics-us/impossible-mass-denoise#33 · Filter by author berlinguyinca opened on Oct 16, 2026
  1

  

• Add an opt-in base-peak guard (keep_top); it halves lost identified-compound matches

  enhancement
  metabolomics-us/impossible-mass-denoise#17 · Filter by author berlinguyinca opened on Oct 7, 2026
  

• Tracking: harm and risk audit of the filter on LC-BinBase data

  bug
  metabolomics-us/impossible-mass-denoise#8 · Filter by author berlinguyinca opened on Oct 6, 2026
  3

  

• Add protection for precursor, base peak and top-3 peaks

  enhancement
  metabolomics-us/impossible-mass-denoise#2 · Filter by author berlinguyinca opened on Oct 6, 2026
  1