Issues

• Thoughts on submission-readiness use cases

  RConsortium/pharma-skills#226 · Filter by author enantz-lilly opened on Oct 23, 2026

• [benchmark][admiral-adpc] ADPC derivation — dose-relative times, dosing records and BLQ handling vs pharmaverseadam::adpc

  benchmark
  RConsortium/pharma-skills#224 · Filter by author jeffreyad opened on Oct 15, 2026

• Documentation

  RConsortium/pharma-skills#220 · Filter by author yudeng2022 opened on Oct 8, 2026
  1

• Register admiral-adrs / admiral-adtte skills and retarget benchmarks #166/#167

  RConsortium/pharma-skills#217 · Filter by author jeffreyad opened on Oct 2, 2026

• adsl skill.md contains a small contradiction

  RConsortium/pharma-skills#216 · Filter by author kieranjmartin opened on Sep 17, 2026

• Consider creating a submission reviewability check skill

  RConsortium/pharma-skills#207 · Filter by author parmsam-pfizer opened on Sep 4, 2026
  

• [benchmark][admiral-bds] ADLB lab toxicity grading — NCI-CTCAE v5.0 directional grading with bidirectional test handling

  benchmark
  RConsortium/pharma-skills#188 · Filter by author jeffreyad opened on Jun 30, 2026
  8

• [feedback][clinical-trial-ipd-sim] AEACN="DISCONTINUED" not set for all AE-discontinued subjects

  RConsortium/pharma-skills#184 · Filter by author lengning opened on Jun 20, 2026

• [feedback][clinical-trial-ipd-sim]Visit timing has zero natural variation

  RConsortium/pharma-skills#183 · Filter by author lengning opened on Jun 20, 2026
  2

• [feedback][clinical-trial-ipd-sim]AE onset dates locked to visit-day grid

  RConsortium/pharma-skills#182 · Filter by author lengning opened on Jun 20, 2026

• [feedback][clinical-trial-ipd-sim] First-Dose Guarantee Not Enforced in Dose Logic Ordering

  RConsortium/pharma-skills#181 · Filter by author lengning opened on Jun 20, 2026

• [feedback][clinical-trial-ipd-sim]Administrative Censoring Lacks Enrollment Stagger Guidance

  RConsortium/pharma-skills#180 · Filter by author lengning opened on Jun 20, 2026

• [feedback][clinical-trial-ipd-sim] AEREL Assignment Not Realistic

  RConsortium/pharma-skills#179 · Filter by author lengning opened on Jun 20, 2026

• [benchmark][group-sequential-design] Non-inferiority trial design — margin justification, M1/M2 framework, and assay sensitivity requirement

  benchmark
  RConsortium/pharma-skills#175 · Filter by author efchea1 opened on Jun 16, 2026
  3

• [benchmark][r2rtf] Kaplan-Meier survival analysis table — median survival, confidence intervals, number at risk, and censoring annotation

  benchmark
  RConsortium/pharma-skills#174 · Filter by author efchea1 opened on Jun 16, 2026

• [benchmark][clinical-trial-simulation] Sample size re-estimation at interim, blinded internal pilot with type I error control

  benchmark
  RConsortium/pharma-skills#173 · Filter by author efchea1 opened on Jun 16, 2026
  4

• [benchmark][admiral-bds] ADPX pharmacokinetics — AUC, Cmax, Tmax derivation with BLQ imputation and missing timepoint handling

  benchmark
  RConsortium/pharma-skills#172 · Filter by author efchea1 opened on Jun 16, 2026
  3

• [benchmark][group-sequential-design] Interim analysis with conditional power and predictive probability of success — DMC decision support

  benchmark
  RConsortium/pharma-skills#171 · Filter by author efchea1 opened on Jun 16, 2026
  2

• [benchmark][group-sequential-design] Platform trial with shared control arm, does the skill correctly adjust for multiplicity from concurrent sub-trial comparisons?

  benchmark
  RConsortium/pharma-skills#169 · Filter by author efchea1 opened on Jun 16, 2026
  3

• [benchmark][clinical-trial-simulation] Bayesian adaptive dose-finding - posterior probability decision rules vs frequentist interim boundaries

  benchmark
  RConsortium/pharma-skills#168 · Filter by author efchea1 opened on Jun 16, 2026
  5

• [benchmark][admiral-adrs] ADRS derivation - RECIST 1.1 tumor response with confirmed best overall response

  benchmark
  RConsortium/pharma-skills#167 · Filter by author efchea1 opened on Jun 16, 2026
  9

• [benchmark][admiral-adtte] ADTTE derivation — time-to-event with correct censoring logic and CNSDTDSC coding

  benchmark
  RConsortium/pharma-skills#166 · Filter by author efchea1 opened on Jun 16, 2026
  7

• [benchmark][admiral-adsl] ADSL safety flag derivation - SAFFL, ITTFL, PPROTFL with correct edge case handling

  benchmark
  RConsortium/pharma-skills#165 · Filter by author efchea1 opened on Jun 16, 2026
  12

• [benchmark][sdtm-oak] AE domain derivation from pharmaverseraw source data

  benchmark
  RConsortium/pharma-skills#159 · Filter by author jeffreyad opened on Jun 13, 2026
  15

• [benchmark][admiral-bds] ADLB derivation from pharmaversesdtm — BDS Findings (laboratory values)

  benchmark
  RConsortium/pharma-skills#149 · Filter by author jeffreyad opened on Jun 1, 2026
  14