This repository contains the manuscript, code and figures for the study Heterogeneity in GLP-1, GIP and glucagon responses during an oral glucose tolerance test.

The manuscript is built using Quarto and LaTeX. The PDF layout follows the Springer Nature journal format from the christopherkenny/nature template.

• Render PDF: Run quarto render manuscript.qmd in the terminal (or click Render in RStudio).

Analysis workflow

The analysis code is organised into five R scripts that should be run in the following order:

1. 01-data-management.r — data management and calculation of analysis variables
2. 02-clustering.r — clustering analysis
3. 03-regression.r — regression analyses
4. 04-sex-stratified-analyses.r — sex-stratified analyses and interaction tests
5. 05-figures.r — generation of main and supplementary figures

Tables and figures

Tables are embedded in the manuscript, while the images/journal folder contains the main and supplementary figures.

Data

The raw data is not included in this repository due to data access and data protection restrictions.

The raw dataset filenames in the scripts reflect project-specific data deliveries and may differ from filenames used in future data deliveries.

Journal-ready figures

code/prepare-journal-figures.r is a convenience script for preparing figures for journal submission. It trims and resizes existing PDF figures to the required dimensions. Figures can preferably be exported at the correct dimensions from the outset, but this script is useful when post-processing is needed.